Makananelo is a human rights and social justice activist from Lesotho. She is particularly passionate about the rights of girls and young women, leading her to co-found an organization called Development and Leadership Centre. The organization advocates for the rights of youth, with a specific focus on the sexual and reproductive health and rights of girls and young women in grassroots communities. She is a Country Coordinator for the International Youth Alliance for Family Planning in Lesotho and holds a Masters Degree in Women's Law from the University of Zimbabwe.